Herpesvu00ecrus mutant of bovine type 5, the vaccine directed against bovine viral encephalitis (BHV - s) and the vu00ecrus ru00e1bico and preparation method of vaccine.

摘要

"Herpesvu00ecrus mutant of bovine type 5, the vaccine directed against bovine viral encephalitis (BHV - 5) and the vu00ecrus ru00e1bico and method of preparation of the vaccine.It is described a mutant of bovine herpesvirus type 5, a vaccine directed against bovine viral encephalitis (BHV - 5) and the virus ru00e1bico and a preparation method of the said vaccine.Being that the mutant of bovine herpesvirus type 5 (BHV - 5) contains a functional deletion in each of at least two genes related to clinical manifestations of neurovirulu00eancia after infection of U.M the host with BHV - 5. In addition, the invention provides a vaccine comprising such a mutant.The invention also provides a method to distinguish a ruminant infected with a sample of wild BHV - 5 or vaccinated against BHV - 5 in a population of ruminants vaccinated with a vaccine accordingWith the invention comprising the test of a ruminant for the presence or absence of antibodies directed against the glycoprotein I (GI), the glycoprotein E (GE) or both.