LIPOSOMIC ANTIBACTERIAL COMPOSITION, OF LOW RIGIDITY.

摘要

THE INVENTION REFERS TO A LIPOSOMAL FORMULATION CONTAINING AT LEAST A LIPOSOMAL FORMULATION CONTAINING AT LEAST A THERAPEUTIC AGENT SUCH AS AN ANTIBIOTIC AND A METHOD TO TREAT BACTERIAL INFECTIONS BY THE ADMINISTRATION OF SUCH FORMULATION. A MULTILAMINARY LIPOSOMAL FORMULATION WITH LITTLE RIGIDITY, FREE OF CHOLESTEROL, IS PREVENTED, INCLUDING A NEUTRAL LIPID AND AT LEAST A THERAPEUTIC AGENT WITH WHICH THE LIPOSOMAL FORMULATION IMPROVES THE PENETRATION OF THE THERAPEUTERIAL AGENT INSIDE THE BULK. A PREFERRED LIPID COMBINATION IS DIPALMITOILPHOSFATIDILCOLINA (DPPC): DIMIRISTOILFOSFATIDILGLICEROL (DMPG) IN A PROPORTION OF 10: 1 TO 15: 1, WITH A TOTAL CONCENTRATION OF LIPID OF BETWEEN 5 AND 85 MM.