LIPOSOME COMPOSITION CONTAINING SELEGILIN, PHARMACEUTICALS CONTAINING LIPOSOMIC COMPOSITIONS, AND PROCESS FOR THEIR PREPARATION

摘要

The liposome composition contains (-) - N-alpha-dimethyl-N- (2-propynyl-phenylethylamine), i.e. selegiline or a salt thereof, as the active ingredient. The composition comprises 0.1 to 40 wt. % selegiline and / or a salt thereof, 2 to 40 wt. % lipid, preferably phospholipid, up to 10 wt. % cholesterol, up to 20 wt. % alcohol, up to 25 wt. % glycol, up to 3 wt. % antioxidants, up to 3 wt. % preservative, up to 2 wt. % viscosity-modifying agent, up to 30 wt. % cyclodextrin or cyclodextrin derivative and 30 to 90 wt. water. The pharmaceutical preparations comprise liposome compositions, conventional fillers and diluents and other adjuvants, preferably in the form for oral, parenteral or transdermal administration, for the treatment of Alzheimer's, Parkinson's disease, depression, stroke, movement disorders and myelitis.