LIPOSOME COMPOSITION CONTAINING SELEGILIN, PHARMACEUTICALS CONTAINING LIPOSOMIC COMPOSITIONS, AND PROCESS FOR THEIR PREPARATION

摘要

The liposome composition contains (-) - N-alpha-dimethyl-N- (2-propynylphenylethylamine) as the active ingredient, i.e. selegiline or a salt thereof. The composition contains 0.1 to 40 wt. % selegiline and / or a salt thereof, 2 to 40 wt. % lipid, preferably phospholipid, up to 10 wt. % of cholesterol, up to 20 wt. % alcohol, up to 25 wt. % glycol, up to 3 wt. % of antioxidants, up to 3 wt. % preservative, up to 2 wt. % viscosity modifying agent, up to 30 wt. cyclodextrin or cyclodextrin derivative and 30 to 90 wt. water. The pharmaceutical compositions comprise liposome compositions, conventional fillers and diluents and other adjuvants, preferably in the form of for oral, parenteral or transdermal administration, for the treatment of Alzheimer's, Parkinson's disease, depression, stroke, locomotive disorders and myelitis.