首页> 外国专利> N-METHYLHYDROXAMIC ACID-BOUND PEPTIDE NUCLEIC ACID, METHOD FOR PRODUCING THE SAME, AND METHOD FOR CLEAVING DNA BY THE SAME

N-METHYLHYDROXAMIC ACID-BOUND PEPTIDE NUCLEIC ACID, METHOD FOR PRODUCING THE SAME, AND METHOD FOR CLEAVING DNA BY THE SAME

机译:N-甲基羟基氧结合的肽核酸,其制备方法和用其切割DNA的方法

摘要

PROBLEM TO BE SOLVED: To provide a specific compound based on a PNA( peptide nucleic acid ), usable as an artificial nucleic acid through cleaving a DNA at a specific site based on the recognition function of PNA on the DNA, to provide a method for producing the compound, and to provide a method for cleaving a DNA by the compound.;SOLUTION: The compound is represented by the general formula( wherein, B is adenine, guanine, cytosine or thymine; n is an integer of 2; and m is an integer of 1 ), which is formed by using an acidic catalytic substance. This compound is an artificial restriction enzyme which is capable of cleaving a specific sequence portion of a DNA having a base sequence complementary to that of this compound by hydrolysis of a phosphodiester bond similarly to the case with a natural enzyme.;COPYRIGHT: (C)2005,JPO&NCIPI
机译:解决的问题:提供一种基于PNA(肽核酸)的特定化合物,该化合物可通过基于DNA上PNA的识别功能在特定位点切割DNA来用作人工核酸,从而提供一种方法解决方案:该化合物由以下通式表示:(其中B是腺嘌呤,鸟嘌呤,胞嘧啶或胸腺嘧啶; n是2的整数;和m是1)的整数,其是通过使用酸性催化物质形成的。该化合物是一种人工限制性酶,类似于天然酶,它能够通过水解磷酸二酯键切割具有与该化合物的碱基序列互补的碱基序列的DNA的特定序列部分。 2005,日本特许厅

著录项

  • 公开/公告号JP2005087088A

    专利类型

  • 公开/公告日2005-04-07

    原文格式PDF

  • 申请/专利权人 CREDIA JAPAN:KK;

    申请/专利号JP20030324380

  • 发明设计人 IKEDA HISAFUMI;WATABE TAKAYOSHI;

    申请日2003-09-17

  • 分类号C12N15/09;C07K7/02;

  • 国家 JP

  • 入库时间 2022-08-21 22:29:59

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