6h dibenzo C, h cromenos replaced as estrogenic agents

摘要

Equation estrogen receptor modulator (1). 1. Claim 1: a formula compound (1),Wherein: each R1 and R2 is independently selected from h, hydroxy, C1-6 tar, c2-6 alquenilo c2-7, Alcoy C1-6 or halogen, and the tar or haloacyl fluorine part of any R1 or R2 can be replaced by hydroxy, halogen, trifluoroalkyl, oxytrifluoride, NO2 or phenyl, but the article is: Subtracting one R1 or R2 is a hydroxyl group; each R3, R4, R5, R6 and R7 is an independent h, C1-6 hydrocarbon, halogen, Alcoy C1-6, - CN, alquenilo c2-7, c2-7 tar, - CHO, phenyl or 5 to 6-member heterocyclic ring, from which or from n or s, one to four heteroatoms are selected, including R4, R5 tar or alquenio,R6 or R7 can be selectively substituted by hydroxy CN, halogen, trifluoroalkyl, oxytrifluoride, NO2 or phenyl; in these substances, the phenyl part of R4 or R5 may be an optional single component.di- or trisubstituted with C1-6 alkyl, C2-7 alkenyl, halogen, hydroxy, C1-6 alkoxy, -CN, NO2, amino, C1-6 alkylamino, C1-6 dialkylamino by alkyl group, thio, C1-6 alkylthio , C1-6 alkylsulfinyl, C1-6 alkylsulfonyl C2-7 alkoxycarbonyl, C2-7 alkylcarbonyl or benzoyl; or a pharmaceutically acceptable salt thereof.