New fused pyrrolo-carbazole or pyrido-pyrrolo-indole derivatives (I), useful for treating cancer

摘要

Fused carbazole and indole derivatives (I), their enantiomers, diastereoisomers and addition salts with acids and bases are new. Fused carbazole and indole derivatives of formula (I), their enantiomers, diastereoisomers and addition salts with acids and bases are new. A = 6-membered ring, saturated, partially or totally unsaturated, including aromatic; Z' = -U'-V'; U' = single bond or 1-6C alkylene, optionally substituted by one or more of halo and hydroxy and optionally containing one or more unsaturations; V' = hydrogen or various substituents; W1 = atoms that complete a phenyl or pyridyl group; W2 = any of 9 specified 5-membered (di)aza heterocyclic groups; X1/X2 = hydrogen, hydroxy, 1-6C alkoxy or alkylthio, or mercapto and then Y1/Y2 = hydrogen, or X1/Y1 and/or X2/Y2 together complete (thio)carbonyl; R1 = hydrogen, 1-6C alkyl (optionally substituted by one or more hydroxy, 1-6C (hydroxy)alkoxy or the group (a), linked to nitrogen through any of Ra to Re; Q = oxygen or NR2; R2 = substituent; Ra to Rd = bond, hydrogen, halo, hydroxy, 1-6C alkoxy or alkyl, aryloxy, aryl(1-6C)alkoxy, aryl, aryl(1-6C)alkyl, NR3R4, -N=N-R3, OCOR5; Re = methylene or -U1-Ra; R3-R5 = substituents; and n = 0 or 1. The full definitions are given in the DEFINITIONS (Full Definitions) Field. An Independent claim is also included for several methods for preparing (I),