Palonosetron clearing pharmaceutical formula

摘要

It refers to the dissolution formula of isoquinol compound (3a) - 2, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 4, 5, 6-hexahydro-1-oxo-1h-benzo (DE), which is called palonosetron. It is characterized by stability before long-term storage and allows the use of a concentration lower than the possible concentration. It is generally expected to be characterised by the presence of palonosetron hydrochloride in the range of about 0.01 mg / ml to 5 mg / ml, as well as a vehicle acceptable in a pH range of about 4.0-6.0 and in a cell acid-base reducing solution of about 10-100 ml,And about 0.005 to 1.0 mg / ml of amphetamine type stimulants. Adding Manitoba and a coagulant can improve the stability of the formula. They are useful tools to reduce spasticity caused by chemotherapy and radiotherapy, and are formulated for injection and oral liquid drug preparation.