Compounds of the saframycin-ecteinascidin series with cytotoxic properties having the following general formula, their uses and synthesis, are disclosed: wherein RSUB1 /SUBand RSUB4 /SUBis H, a CSUB1 /SUBto CSUB4 /SUBalkyl group, or an acyl group; wherein RSUB2 /SUBis an ether, ester, amide, or a phthalimide group; wherein RSUB3 /SUBis -O, OH, an ether group, an acyl group such as OC(O)Me, OC(O)Bn and OC(O)Et, or a sulfide group; wherein RSUB5 /SUBis H, halogen, OH, an ether group, an acyl group, or an amide group; wherein RSUB6 /SUBis -O, OH, OCHSUB3/SUB, CN, or an acyloxy group; wherein RSUB7/SUB, is -O, OH, halogen, an ether group, or an acyl group; wherein RSUB8 /SUBand RSUB9 /SUBare independently H, CHSUB3/SUB, OCHSUB3/SUB, OCSUB2/SUBHSUB5/SUB, CFSUB3/SUB, halogen such as Br and F, or RSUB8 /SUBand RSUB9 /SUBare joined together as a methylenedioxy group, or other five or six membered ring; wherein RSUB10 /SUBand RSUB11 /SUBare independently CHSUB3/SUB, OCHSUB3/SUB, OCSUB2/SUBHSUB5/SUB, SCHSUB3/SUB, or SCSUB2/SUBHSUB5/SUB; wherein RSUB12 /SUBis H, a CSUB1 /SUBto CSUB4 /SUBalkyl group, or an acyl group; and wherein the chiral center marked * has the R or the S configuration.
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