NUCLEOSIDE ANALOG PHOSPHORAMIDATES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPRODUCTION

摘要

FIELD: organic chemistry, biochemistry, medicine.;SUBSTANCE: invention relates to phosphoramidates of nucleoside analogs comprising 2',3'-dideoxy-2',3'-didehydrothymidine 5'-phosphodimorpholidate of the formula (I) and phosphoramidates of 3'-azido-3'-deoxythymidine of the formula (II) and the formula (III) that inhibit activity in reproduction of human immunodeficiency virus (HIV). Compounds are resistant to effect of dephosphorylating enzymes and able to penetrate into cells and elicit the selective activity in inhibition of DNA biosynthesis catalyzed by HIV-reverse transcriptase.;EFFECT: valuable medicinal and biochemical properties of nucleoside analogs.;4 dwg, 1 tbl, 5 ex