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4-Amino-quinazoline derivatives and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases

机译:4-氨基喹唑啉衍生物和喹啉衍生物对酪氨酸激酶介导的信号转导具有抑制作用

摘要

The present invention relates to bicyclic heterocycles of general formula wherein R a to R d , A to G and X are defined as in claim 1, the tautomers, the stereoisomers and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable pharmacological properties, particularly an inhibiting effect on signal transduction mediated by tyrosine kinases, their use for treating diseases, particularly tumoral diseases, diseases of the lungs and respiratory tract, and the preparation thereof.
机译:本发明涉及通式的双环杂环其中R a至R d,A至G和X如权利要求1所定义,互变异构体,立体异构体及其盐,特别是其与具有有价值的药理特性的无机或有机酸或碱的生理可接受的盐,特别是对酪氨酸激酶介导的信号转导的抑制作用,它们在治疗疾病特别是肿瘤疾病,肺和呼吸道疾病中的用途及其制备。

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