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Delivery System in the form of a Ring of two steroids and an antimicrobial for vaginal Administration

机译:两种类固醇环和一种用于阴道给药的抗菌剂形式的给药系统

摘要

1. A drug release system, wherein at least one part is composed of (I) a core containing a thermoplastic polymer, (II) an intermediate layer containing a thermoplastic polymer, (III) a non-medical thermoplastic polymer shell covering the intermediate layer, The intermediate layer is loaded with (a) crystal of the first active substance and (b) dissolution form of the second active substance, and the second active substance is loaded on the basis of dissolution.to claim 1 which is physically stable at about 18 - 30 ° C. 3.- A drug releasing system according to claim 1 where said second compound in the nucleus is present in the same concentration as in the intermediate layer .4.- A drug delivery system according to claim 1The characteristic of this system is that the release system is basically a ring-shaped one, which aims to control the release of vagina l.5-according to the first requirement, the first active compound is steroids, and the second active compound is steroids. According to the fifth requirement, namely, the first effective steroid is a progesterone, the second effective steroid is an estrogen, and the first effective steroid is a drug release system,Estrogen is the system for the release of drugs according to Item 6, in which progesterone is etonogretrel
机译:1.一种药物释放系统,其中至少一部分由(I)包含热塑性聚合物的芯,(II)包含热塑性聚合物的中间层,(III)覆盖所述中间层的非医学热塑性聚合物壳组成7.根据权利要求1所述的中间层,其在(a)第一活性物质的晶体和(b)第二活性物质的溶解形式中负载,并且在溶解的基础上负载第二活性物质。 18- 30°C。3.根据权利要求1的药物释放系统,其中所述第二化合物在细胞核中的浓度与在中间层中的浓度相同。4.-根据权利要求1的药物释放系统该系统的释放系统基本上是环形的,其目的是根据第一个要求控制阴道l.5的释放,第一个活性化合物是类固醇,第二个活性化合物是类固醇。根据第五要求,即第一有效类固醇是孕激素,第二有效类固醇是雌激素,并且第一有效类固醇是药物释放系统,雌激素是根据第6项所述的药物释放系统。哪个孕激素是依托格雷

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