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PRENIL TRANSFERASA INHIBITORS.

机译:苯酚转移酶抑制剂。

摘要

A compound of Formula III or Formula IV; Formula III Formula IV in which Y is CH2 or C (O); R1, R2, R3, and R4, are each independently, H, C1-C6 alkyl, or an optionally substituted moiety selected from the group consisting of C1-C18 arylalkyl, C2-C18 alkenyl, C1-C18 aliphatic acyl, and arylacil; R5 and R6 are each independently, H or CH3; R9 and R10 are each independently selected from the group consisting of H, C1-C6 alkyl, and C3-C6 cycloalkyl; Ar is an optionally substituted moiety selected from the group consisting of aryl and heterocycle; n is 0 or an integer between 1 and 4; wherein each optionally substituted moiety is optionally substituted by one or more substituents independently selected from the group consisting of aryl, heterocycle, halogen, OR9, NR9R10, CN, NO2, CF3, or C1-C6 alkyl, said optionally substituted C1-C6 alkyl with C1-C4 alkoxy, NR9R10, C3-C6 cycloalkyl, or OH; or one of its pharmaceutically acceptable salts, with the proviso that the compound is not the
机译:式III或式IV的化合物;式III式IV其中Y为CH 2或C(O); R1,R2,R3和R4分别独立地是H,C1-C6烷基或选自C1-C18芳基烷基,C2-C18烯基,C1-C18脂族酰基和芳基的任选取代的部分; R5和R6各自独立地为H或CH3; R9和R10各自独立地选自H,C1-C6烷基和C3-C6环烷基; Ar是选自芳基和杂环的任选取代的部分; n为0或1到4之间的整数;其中每个任选取代的部分任选地被一个或多个独立地选自芳基,杂环,卤素,OR9,NR9R10,CN,NO2,CF3或C1-C6烷基的取代基取代,所述任选取代的C1-C6烷基为C1-C4烷氧基,NR9R10,C3-C6环烷基或OH;或其一种药学上可接受的盐,条件是该化合物不是

著录项

  • 公开/公告号ES2258332T3

    专利类型

  • 公开/公告日2006-08-16

    原文格式PDF

  • 申请/专利号ES19990926104T

  • 发明设计人 KIM SUN H.;

    申请日1999-06-01

  • 分类号C07D513/04;A61K31/55;A61K31/495;C07D513/14;C07D241/04;C07D285/36;C07D285/38;C07K5/06;A61K38/05;

  • 国家 ES

  • 入库时间 2022-08-21 21:35:49

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