GENETIC POLYMORPHISM IN PNLPA3 ASSOCIATED WITH LIVER FIBROSIS METHODS OF DETECTION AND USES THEREOF

摘要

The present invention is based on the discovery of genetic polymorphisms thatare associatedwith liver fibrosis and related pathologies. In particular, the presentinvention relates to nucleicacid molecules containing the polymorphisms, variant proteins encoded by suchnucleic acidmolecules, reagents for detecting the polymorphic nucleic acid molecules andproteins, andmethods of using the nucleic acid and proteins as well as methods of usingreagents for theirdetection.