In a method and related capsule filling machine for producing sealed capsules (C), each defined by a body (1) coupled with a lid (2), the capsule body (1) is filled with a quantity or dose (3) of material, especially pharmaceutical material in liquid or powder form, and the capsule (C) is closed by placing the lid (2) over the body (1) so that their respective annular ends (la, 2a) overlap. A sealing substance is applied to at least one of the overlapped ends (la, 2a) of the capsule body (1) and lid (2) before the capsule (C) is closed.
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