首页> 外国专利> Dual-Transfected Cells Lines As In Vitro Screening Tools For Pharmaceutical Compound Profiling: A Model For The Heptobiliary Elimination

Dual-Transfected Cells Lines As In Vitro Screening Tools For Pharmaceutical Compound Profiling: A Model For The Heptobiliary Elimination

机译：双转染细胞系作为药物复合物分析的体外筛选工具：肝胆消除模型

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摘要

The invention is referring to several dual-transfected cell lines expressing human NTCP (Na/taurocholate Cotransporting Protein; SLC10A1) together with human BSEP (Bile Salt Export Pump; ABCB11) or human MRP2 (Multidrug Resistance Protein; ABCC2) suitable as an in vitro tool for pharmaceutical compound profiling particularly as a model for hepatobiliary elimination.

机译：本发明涉及表达适合于在体外表达人NTCP（钠/牛磺胆酸盐共转运蛋白; SLC10A1）以及人BSEP（胆盐输出泵; ABCB11）或人MRP2（多药抗性蛋白; ABCC2）的几种双转染细胞系。用于药物化合物分析的工具，特别是作为肝胆消除模型。

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公开/公告号US2007287167A1

专利类型
公开/公告日2007-12-13

原文格式PDF
申请/专利权人 STEFAN THEIS;TANJA EISENBLAETTER;
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申请/专利号US20050594419
发明设计人 TANJA EISENBLAETTER;STEFAN THEIS;
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申请日2005-04-08
分类号C12N5/06;C12M1/22;C12N15/87;C12Q1/02;C12N5/02;
国家 US
入库时间 2022-08-21 20:15:29

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