DUAL-TRANSFECTED CELLS LINES AS IN VITRO SCREENING TOOLS FOR PHARMACEUTICAL COMPOUND PROFILING: A MODEL FOR HEPTOBILIARY ELIMINATION

摘要

The invention is referring to several dual-transfected cell lines expressing human NTCP (Na/taurocholate Cotransporting Protein; SLC10A1) together with human BSEP (Bile Salt Export Pump; ABCB11) or human MRP2 (Multidrug Resistance Protein; ABCC2) suitable as an in vitro tool for pharmaceutical compound profiling particularly as a model for hepatobiliary elimination.