insulin-like growth factor-i conjugates (igf-i) and polyethylene glycol

摘要

"Conjugates of Insulin-like Growth Factor-I (OGF-I) and Polyethylene Glycol". The present invention relates to a conjugate consisting of an insulin-like growth factor-I variant (IGF-I) and one or two polyethylene glycol groups characterized by the fact that said IGF-I variant has an alteration of amino acid at up to three amino acid positions 27.37, 65.68 of the wild-type IGF-I amino acid sequence so that one or two of said amino acids is / are lysine and amino acid 27 is a different polar amino acid than lysine, and is conjugated via the aminopriminal group (s) of lysine (s) to said polyethylene glycol group (s) having a total molecular weight of 20 kDa to 100 kDa . This conjugate is useful for treating neurodegenerative disorders such as Alzheimer's disease.