substituted aromatic arylsulfonylmethyl or arylsulfonamide compounds suitable for treating disorders responsive to dopamine d3 receptor modulation

摘要

ARSULFONILMETIL OR AROMSULFONAMIDE COMPOUNDS REPLACED SUITABLE FOR TREATING DISORDERS RESPONDING TO DOPAMINE D-3 ~ RECEIVER MODULATION. The present invention relates to aromatic compounds of formula (I) wherein Ar is phenyl or a 5- or 6-membered C-linked heteroaromatic radical, wherein Ar may carry 1 radical R¬a¬ and wherein Ar may also carry 1 or 2 R sym radicals; X is N or CH; Y is O, S, -CH = N-, -CH = CH- or -N = CH-; A is CH ~ 2 ~, O or S; E is CR¬ 6¬R¬ 7¬ or NR¬ 3¬; R 1 is C 1 -C 4 alkyl, C 3 -C 4 cycloalkyl, C 3 -C 4 cycloalkylmethyl, C 3 -C 4 alkenyl, alkyl C 1 -C 4 fluorinated, C 3 -C 4 cycloalkyl fluorinated, C 3 -C 4 cycloalkylmethyl fluorinated, C 3 -C 4 fluorinated alkenyl, formyl or C 1-4 alkylcarbonyl ~ 2 ~ -C ~ 3; R¬ 1 [¬ is H, C 2 -C 4 alkyl, C 3 -C 4 cycloalkyl, C 3 -C 4 alkenyl, C 1 -C 4 alkyl fluorinated, fluorinated C 3 -C 4 cycloalkyl, or R 1 and R 2 together are (CH 2) with n being 2 or 3, or R 1 and R¬ 2 [¬ together are (CH ~ 2 ~) ~ n ~ with n being 2 or 3; R¬ 2¬ and R¬2 [¬ are independently H, CH ~ 3 ~, CH ~ 2 ~ F, CHF ~ 2 ~ or CF ~ 3 ~; R 3 is H or C 1 -C 4 alkyl; R 6, R 7, independently of each other, are selected from H, C 1 -C 2 alkyl, and C 1 -C 2 fluorinated alkyl; and their physiologically tolerated acid addition salts. The invention also relates to the use of a compound of formula I or a pharmaceutically acceptable salt thereof to prepare a pharmaceutical composition for the treatment of a medical disorder susceptible to treatment with a dopamine D3 receptor ligand.