methods for screening angiogenesis inhibiting drug candidates, inhibiting tumor growth, inhibiting angiogenesis, and promoting tumor necrosis in a mammal

摘要

METHODS FOR TREATING DRUG CANDIDATES THAT INHIBIT ANGIOGENESIS, INHIBIT TUMOR GROWTH, INHIBIT ANGIOGENESIS, AND PROMOTE TUMOR NECROSIS IN A MAMMALIAN. The invention relates to the Duffy antigen receptor for chemokines and its uses. In one embodiment, the invention provides a method for selecting candidates for angiogenesis inhibiting drugs. The method comprises contacting a molecule with a Duffy antigen receptor for chemokines and determining whether the molecule binds at the Duffy antigen receptor for chemokines. In another embodiment, the invention provides a method for inhibiting tumor growth. In yet another embodiment, the invention provides a method for inhibiting angiogenesis. In another embodiment, the invention provides a method for promoting tumor necrosis.