Process for preparing salts of 2-2-(4-dibenzob,f1,4thiazepin-11-yl-1-piperazinyl)ethoxyethanol (quetiapine) and purification process of such salts

摘要

method for preparing salts of 2 - (2 - (4 - dibenzo [b, f] [1,4] thiazepin-11 -) - 1-piperazinyl) - ethoxy] ethanol (quetiapinu) from the base quetiapinu and the acid, where salt is eliminated from the mixture of solventswhich is either a mixture of aromatic uhlovodu00edkua ketone or ester or aromatic hydrocarbon, water and ketone or ester.purification of salt quetiapinu by partial crystallization, when, in the alcohol c.sub.1.n. to c.sub.6.n. dissolved only a part of the salt quetiapinu.