A process for the preparation of a novel 3-hydroxy-5-(tert.butyldimethyl silyloxy)-(1S,3R,5R)-cyclohexylacetate useful as an intermediate for veta-hydroxy delta-lactone.

摘要

The present invention provides a process for the preparation of a novel 3-hydroxy-5- (tert.butyldimethylsilyloxy)-(15,3R,5R)-cyciohexylacetate useful as an intermediate for 6-hydroxymethyl-4-(tert-butyldimethylsilyloxy)-(4R,6S)-tetrahydro-2H-2- pyranone (ß-hydroxy-δ-lactone) having formula 1. (Formula Removed) More particularly the present invention provides a process for the preparation of a novel 3-hydroxy-5-(tert.butyldimethylsilyloxy)-(15,3R,5R)-cyclohexylacetate having formula 5 (Formula Removed) from a compound cis,cis-3-(methylcarbonyloxy)-5-(tert.butyldimethylsilyloxy) cyclohexylacetate having formula 4. (Formula Removed)