a process for the preparation of a novel 3-hydroxy-5-(tert.butyldimethyl silyloxy)-(3S,5R)-cyclohexan-1-one useful as an intermediate for Beta-hydroxy Game-lactone

摘要

A process for the preparation of a novel 3-hydroxy-5-(tert.butyldimethyl silyloxy)-(3S,5R)-cyclohexan-1-one useful as an intermediate for ß-hydroxy γ-lactone by reacting a compound 3-tetrahydro-2H-2-pyranyloxy-5-(tert.butyldimethylsilyloxy)-(1S.3R, 5R) -cyclohexan-1-one with magnesium bromide in an aliphatic organic solvent at a temperature ranging from 5 to 30°C for a period from 1 to 12 hours, quenching the above reaction with ammonium chloride, separating organic layer, drying and on evaporating to obtain 3-hydroxy-5-(tert.butyldimethylsilyloxy)-(3S,5R)-cyclohexan-1-one.