EXPRESSION VECTORS FOR MULTIPLE GENE INTEGRATION AND OVEREXPRESSION OF HOMOLOGOUS AND HETEROLOGOUS PROTEINS IN YEASTS OF THE GENUS ARXULA

摘要

The present invention relates to expression vectors which can be utilized in yeasts of the genus Arxula, especially in the yeast Arxula adeninivorans, for multiple, chromosomal gene integration and, as a result, for higher production of heterologous proteins. The invention additionally relates to methods for expressing heterologous proteins, methods for producing host cells of the genus Arxula, and kits, host cells and pharmaceutical compositions.