PURIFICATION AND PROTECTIVE EFFICACY OF MONODISPERSE AND MODIFIED YERSINIA PESTIS CAPSULAR F1-V ANTIGEN FUSION PROTEINS FOR VACCINATION AGAINST PLAGUE

摘要

This disclosure concerns compositions and methods for the treatment and inhibition of infectious disease, particularly bubonic and pneumonic plague. In certain embodiments, the disclosure concerns immunogenic proteins, for instance substantially monodisperse F1-V fusion proteins, that are useful for inducing protective immunity against Y. pestis.