The present invention is related to the discovery that phosphorylation of SP1 (SEQ ID NO.: 2) at serine residue 101 (known herein as phosphoserine101 Sp1) is an important part of a cell's response to DNA damage. This phosphorylation event is important for subsequent Sp1 localization to a site of DNA damage and is correlated with increased cellular viability in response to DNA damage.
展开▼
机译:本发明涉及以下发现:在丝氨酸残基101(本文称为phosphoserine 101 Sup> Sp1)上SP1(SEQ ID NO .: 2)的磷酸化是细胞对DNA损伤反应的重要组成部分。 。此磷酸化事件对于随后的Sp1定位到DNA损伤的部位很重要,并且与响应DNA损伤的细胞活力增加相关。
展开▼