pharmaceutically acceptable salts of 2,4,6-trimethyl-3-hydroxypyridine with lower dicarboxylic acids and method for preparing same

摘要

PHARMACEUTICALLY ACCEPTABLE SALTS OF 2,4,6-TRIMETHYL-3-HYDROXYPYRIDINE, WITH LOWER DICARBOXYLIC ACIDS AND METHOD FOR PREPARING THEM. The present invention relates to the field of medicaments, notably novel biologically active compounds, specifically to 2,4,6-trimethyl-3-hydroxypyridine derivatives and salts thereof (compound 1), having antioxidant, geroprotective and anti-ischemic. The salts of compound (1) are prepared by reacting eqimolar amounts of 2,4,6-trimethyl-3-hydroxypyridine and dicarboxylic acid in a solution of an alcohol below 60-100 ° C, followed by treatment. of the reaction mass with an organic solvent for 2-5 hours at a temperature of 10-15 ° C.