TWO VACCINE COMPOSITIONS COMPRISING MUTATED STRAIN OF SALMONELLA TYPHI AND SALMONELLA TYPHIMURIUM

摘要

The present invention relates to obtaining two vaccine composition comprising mutated strain of Salmonella typhi and Salmonella typhimurium optionally along with pharmaceutically acceptable carriers; a process to obtain two vaccine composition comprising mutated strain of Salmonella typhi and S. typhimurium optionally along with pharmaceutically acceptable carriers, wherein the process comprises steps of: (a) obtaining mutated strain of Salmonella typhi and S. typhimurium by lambda red recombination system; and (b) optionally mixing the mutated strain with pharmaceutically acceptable carriers to obtain said composition; a strain of Salmonella typhi carrying mutation from STY 2527-2534 and Styphimurium carrying mutation from STM2296-STM2304 in the virulence gene.