The present invention provides a micro-fluidic system, a method for manufacturing a micro-fluidic system and a method for controlling or manipulating a fluid flow through micro-channels of such a micro-fluidic system. The inner side of the wall of the micro-channel is provided with actuator elements. These actuator elements have a shape, an orientation and a geometry that includes a varying cross sectional area along a longitudinal axis. The varying cross sectional area includes one or more openings along the longitudinal axis of the actuator element. The actuator elements can change in shape and orientation as a response to an external stimulus. Through this change of the shape and orientation, the flow of a fluid through a micro-channel may be controlled and manipulated.
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