NOVEL LONG-CHAIN FATTY ACID DERIVATIVE COMPOUND AND G-PROTEIN-COUPLED RECEPTOR AGONIST CONTAINING THE COMPOUND AS ACTIVE INGREDIENT

摘要

It is intended to provide a novel long-chain fatty acid derivative compound having an agonistic activity to GPR120 and GPR40. The long-chain fatty acid derivative compound of the invention is represented by the following general formula (I). In the formula, m+n means an integer of 20 or less, R means a hydrogen atom or an ester residue, Y1 and Y2 mean a halogen atom, the ring Q means a carbocyclic group or a heterocyclic group which may be condensed, X1, X2, and X3 mean a hydrogen atom, a halogen atom, or the like, W means -C(=N-OR1)-, -CH(NR2R3)- or -CH(N3)-. A medicament containing the long-chain fatty acid derivative compound as an active ingredient is effective as an appetite regulating agent, an antiobesity agent, a therapeutic agent for diabetes, a pancreatic beta cell proliferation and differentiation accelerator, a therapeutic agent for metabolic syndrome, a therapeutic agent for gastrointestinal diseases, a therapeutic agent for neuropathy, a therapeutic agent for psychiatric disorder, a therapeutic agent for lung diseases, a therapeutic agent for pituitary hormone deficiency, and a fat flavor seasoning.