CD40 signalling inhibitor and a further compound, wherein the further compound is a bile acid, a bile acid derivative, an TGR5-receptor agonist, an FXR agonist or a combination thereof, for the treatment of chronic inflammation, and the prevention of gastrointestinal cancer or fibrosis.

摘要

The invention provides a CD40 signalling inhibitor and a further compound for use in the treatment of chronic inflammatory disease in an individual in need thereof, wherein the further compound is a bile acid, a bile acid derivative, an TGR5-receptor agonist, an FXR-receptor agonist or a combination thereof. Also provided is a CD40 signalling inhibitor and a further compound for use in the prevention of cancer and/or fibrosis, wherein the further compound is a bile acid, a bile acid derivative, an TGR5-receptor agonist, an FXR-receptor agonist or a combination thereof.