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CD40 SIGNALLING INHIBITOR AND A FURTHER COMPOUND, WHEREIN THE FURTHER COMPOUND IS A BILE ACID, A BILE ACID DERIVATIVE, AN TGR5-RECEPTOR AGONIST, AN FXR AGONIST OR A COMBINATION THEREOF, FOR THE TREATMENT OF CHRONIC INFLAMMATION, AND THE PREVENTION OF GASTROINTESTINAL CANCER OR FIBROSIS.
CD40 SIGNALLING INHIBITOR AND A FURTHER COMPOUND, WHEREIN THE FURTHER COMPOUND IS A BILE ACID, A BILE ACID DERIVATIVE, AN TGR5-RECEPTOR AGONIST, AN FXR AGONIST OR A COMBINATION THEREOF, FOR THE TREATMENT OF CHRONIC INFLAMMATION, AND THE PREVENTION OF GASTROINTESTINAL CANCER OR FIBROSIS.
The invention provides a CD40 signalling inhibitor and a further compound for use in the treatment of chronic inflammatory disease in an individual in need thereof, wherein the further compound is a bile acid, a bile acid derivative, an TGR5-receptor agonist, an FXR-receptor agonist or a combination thereof. Also provided is a CD40 signalling inhibitor and a further compound for use in the prevention of cancer and/or fibrosis, wherein the further compound is a bile acid, a bile acid derivative, an TGR5-receptor agonist, an FXR-receptor agonist or a combination thereof.
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