NOVEL ANTI-ARRHYTHMIC AND HEART FAILURE DRUGS THAT TARGET THE LEAK IN THE RYANODINE RECEPTOR (RYR2) AND USES THEREOF

摘要

The present application relates to benzothiazepine S36 and its oxidized derivatives tor use in limiting or preventing a decrease in the level of RyR2-bound FKBP12.6 in a subject having a cardiac condition or in treating or preventing a cardiac condition in a subject.