Discussion on the Mechanism of Action of High-frequency Drugs for Treating Heart Failure Based on Network Pharmacology

摘要

Objective:To explore the target and mechanism of Astragalus membranaceus,poria,salvia miltiorrhiza and semen leiocarpa in the treatment of heart failure by network pharmacology.Methods:The active components of traditional Chinese medicine and the target of heart failure were screened by multi-platform,and the standard gene was transformed by Uniprot.CytoCasp 3.6.1 was used to draw the network diagram of traditional Chinese medicine・component-target.Go and KEGG analysis were performed by Metascape.Results:A total of 36 predictive target sites of Radix Astragalus,Fuling poria,Salvia miltiorrhiza and Draba nemorosa were screened for treatment of heart failure,mainly involving nerve and factor pathways:ADRB2,ADRA1B and AChE.Cancer pathway:TP53,TNF;Pathways of inflammation:IL1B,PTSG2,PTSG1;Sex hormone pathway:ESRI,AR,PGR;Others:SCN5A,HIF1A,etc.The results of GO and KEGG enrichment suggested that the treatment of heart failure with the top four drugs involved cancer pathway,calcium signaling pathway,HIF-1 signaling pathway,and involved in blood circulation,cell proliferation and other processes.Conclusion:This study combines the pharmacological studies of Chinese medicine and western medicine to reveal the mechanism of multi-target and multi-channel regulation of body balance in Chinese medicine treatment.