Analysis of Action Mechanism of Fuxin Decoction on Heart Failure Based on Network Pharmacology

摘要

[Objectives]The purpose was to analyze and predict the mechanism of Fuxin decoction in the treatment of heart failure based on network pharmacology.[Methods]Relevant tools and methods of network pharmacology were used to obtain the active ingredients and action targets of Fuxin decoction and action targets of heart failure,find out the key targets and core clusters of Fuxin decoction on heart failure,and analyze related signal pathways,to explore possible molecular mechanisms.[Results]A total of 53 active ingredients and 224 action targets of Fuxin decoction,1010 heart failure-related target genes,and 94 drug-disease directly acting targets were obtained.From the PPI network constructed,225 key targets and a core cluster composed of 56 nodes and 297 interactions were screened out.Association with tumors,glutamate synapse and other related pathways and related genes such as adenylate cyclase and MAPK were known.[Conclusions]The mechanism of Fuxin decoction in the treatment of heart failure is related toβARs-G protein-adenylate cyclase,PI3K-Akt signaling pathway and HSP90,MAPK and other proteins.