CGRP-antagonists receptor, compositions containing them and methods of treating migraine with their use

摘要

1. A compound of formula I wherein R is Ci ^ alkyl, alkenyl, cycloalkyl, Stsikloalkenil, C (cycloalkyl) alkyl, Cgalogenalkil, C (alkoxy) alkyl, C (Ar) alkyl, C (NRR) alkyl, N- (R) -pyrrolidinyl or N - (R) piperidinyl; R is hydrogen, halogen, hydroxy, Ci ^ alkyl, alkenyl, benzyloxy, or NRR; R is hydrogen, hydroxy, halogen, Ci ^ alkyl, or alkenyl; or R together represent Rvzyatye CHNNR; R is hydrogen, halo or Ci ^ alkyl, or alkenyl; R is hydrogen or Ci ^ alkyl; R is hydrogen, Ci ^ alkyl ,, or; or NRR, taken together represents or ,,,,,,; R is hydrogen or Ci ^ alkyl; R is hydrogen or Ci ^ alkyl; iliNRRvzyaty together is selected from the group consisting of pyrrolidinyl, piperidinyl, N- (R) piperazino, morpholinyl, and thiomorpholinyl; R is hydrogen, Ci ^ alkyl, alkylcarbonyl, or alkoxycarbonyl; R is phenyl, naphthyl, pyridinyl, N-oxide, pyridinyl, quinolinyl , quinolinyl N-oxide, isoquinolinyl N-oxide, or isoquinolinyl, and is substituted by 0-2 substituents selected from the group consisting of halogen, Ci ^ alkyl Cgalogenalkila, alkoxy, hydroxy and phenyl, or R c is selected from the group consisting of, and ,,,,,,,,,,,,,,,,,,,,,,,,,,,; is independently a bout hydrogen, halogen, Ci ^ alkyl Cgalogenalkil or alkoxy; Arpredstavlyaet is phenyl, naphthyl, pyridinyl, or imidazolyl, and is substituted by 0-2 substituents selected from the group consisting of halogen, Ci ^ alkyl and Sgalogenalkila; Arpredstavlyaet is phenyl, naphthyl or pyridinyl and is substituted by 0-2 substituents selected from the group consisting of halogen, Ci ^ alkyl and Cgalogenalkila; XY represents aminocarbonyl, oxycarbonyl, IU