Prodrug compound of a compound originating from pharmaceutical composition processes to antagonize the effect of substance p at its receptor site or to block neurokinin-1 receptors in a mammal to treat or prevent pain or nociception attributable to or associated with migraine a condition selected from the group consisting of of AIDS-related peripheral diabetic neuropathy induced by chemotherapy and neuralgia asthma emesis and arthritis to treat cystic fibrosis and process to prepare

摘要

Substituted heterocycles of the general structural formula: IMAGE are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma, emesis and nausea.