Compound process to produce the same pharmaceutical compositions to antagonize the tachykinin receptor to antagonize a neurokinin receptor a to prevent or treat urination disorders asthma disorders rheumatoid arthritis osteoarthritis migraine pain cough irritable bowel syndrome or emesis processes to antagonize tachykinin receptor in mammals to prevent or treat urination disorders in mammals to prevent or treat asthma disorders migraine irritable bowel syndrome pain cough and emesis in mammals and use of the compound

摘要

Novel compounds of the following general formula or salts thereof. CHEM wherein Ring M is a heterocyclic ring having -N=C, -CO-N or -CS-N as the partial structure -X @ Y; Ra and Rb are bonded to each other to form Ring A, or they are the same or different and represent, independently, a hydrogen atom or a substituent on the Ring M; Ring A and Ring B represent, independently, an optionally substituted homocyclic or heterocyclic ring, and at least one of them is optionally substituted heterocyclic ring; Ring C is optionally substituted homocyclic or heterocyclic ring; Rng Z is an optionally substituted ring; and n represents an integer of from 1 to 6, or a salt thereof, which has an excellent tachykinin receptor antagonistic effect, and their production, and pharmaceutical compositions.