Pharmaceutical composition, compound, prodrug, compositions to antagonize a receptor, use of a compound, and, processes to produce a compound, to antagonize a receptor, to prevent or treat urination disorders in mammals and asthma disorders, rheumatoid arthritis, osteoarthritis, pain, cough, irritable bowel syndrome or vomiting in mammals

摘要

"PHARMACEUTICAL COMPOSITION, COMPOUND, PRE-MEDICINAL PRODUCTS, COMPOSITIONS TO ANTAGONIZE A RECEPTOR, USE OF A COMPOUND, AND, PROCESSES TO PRODUCE A COMPOUND, TO ANTAGONIZE A RECEPTOR, TO AVOID OR TREAT DETERMINATIONS OF MICROMYTS IN MYMATERIC DETERMINES IN MYMETHYROMINISTS. , OSTEOARTHRITIS, PAIN, COUGH, IRRITABLE GUT SYNDROME OR VOMITING IN MAMMALIAN ". A compound represented by formula (I): in which ring M is a heterocyclic ring in which formula (a): is one of -N = C , -CO-N or -CS-N ; R ^ a ^ and R ^ b ^ are attached to each other to form ring A, or are the same or different and independently represent a hydrogen atom or a substituent on ring M; ring A and ring B independently represent an optionally substituted homocyclic or heterocyclic ring, with the proviso that at least one of them is an optionally substituted heterocyclic ring; ring C is an optionally substituted homocyclic or hetecocyclic ring; the Z ring is an optionally substituted nitrogen containing heterocyclic ring; and n is an integer from 1 to 6, or a salt of these has an antagonistic activity to the tachykinin receptor in vitro, and is usable to prevent or treat depression, anxiety, illness or manic depressive psychopathy.