compound, pharmaceutical composition, and methods for antagonizing cgrp receptor activity in a mammal to treat, control, ameliorate or reduce the risk of headache, migraine or headache, and treating or preventing migraine headaches. , headaches, and headaches

摘要

COMPOSITION, PHARMACEUTICAL COMPOSITION, AND METHODS FOR ANTIGONISM OF CGRP RECEIVER ACTIVITY IN A MAMMER, TO TREAT, CONTROL, IMPROVE OR REDUCE THE RISK OF HEADACHE, THRESHEME OR PREFACTURE OF HEADACHES , HEADACHES, AND HEADACHES. The invention relates to compounds of Formula (I) and Formula (II): (wherein the variables R 1, R 4, A, B, D, W, X, Y and Z are as defined herein) as CGRP receptor antagonists and useful in treating or preventing diseases in which CGRP is involved, such as headache, migraine, and crowded headache. The present invention is also directed to pharmaceutical compositions comprising these compounds and to the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.