首页> 外国专利> STENTS WITH COATING CONTAINING N-{5-4-(4-METHYLPIPERAZINOMETHYL)BENZOYL-AMIDO-2-METHYLPHENYL}-4-(3-PYRIDYL)-2-PYRIMIDINAMIN

STENTS WITH COATING CONTAINING N-{5-4-(4-METHYLPIPERAZINOMETHYL)BENZOYL-AMIDO-2-METHYLPHENYL}-4-(3-PYRIDYL)-2-PYRIMIDINAMIN

机译:含有N- {5- [4-(4-甲基哌嗪甲基)苯甲酰基-酰胺基] -2-甲基苯基} -4-(3-吡啶基)-2-嘧啶的涂料

摘要

FIELD: medicine.;SUBSTANCE: offered is medical device adapted for local application or introduction in hollow tubes and containing therapeutic dose of N-{5-[4-(4-methylpiperazinomethyl) benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidinamine or its salt, crystal form with possible release thereof, its application for prevention or reduction of dysfunction caused by approach to vessels and related method of treatment (prevention). Particularly offered is method of restenosis treatment or prevention inpatients suffering from diabetes. It is detected that local introduction of M-{5-[4-(4-methylpiperazinomethyl) benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidinamine or its pharmaceutically acceptable salt or crystal form under declared method provides unexpectedly high stability of compound within 45 days compared to its activity value when introduced as free form.;EFFECT: provides high stability of compound.;5 cl, 7 ex
机译:领域:药物;提供的是一种适于局部应用或引入中空管并包含治疗剂量的N- {5- [4-(4-甲基哌嗪子甲基)苯并酰胺基] -2-甲基苯基} -4-(3)的医疗装置-吡啶基)-2-嘧啶胺或其盐,可能释放的晶形,其在预防或减少因接近血管而引起的功能障碍中的用途以及相关的治疗方法(预防)。特别提供了再狭窄治疗方法或预防患有糖尿病的住院患者的方法。检测到在声明的方法下局部引入了M- {5- [4-(4-甲基哌嗪子甲基)苯并酰胺基] -2-甲基苯基} -4-(3-吡啶基)-2-嘧啶胺或其药学上可接受的盐或晶体形式与以游离形式引入时的活性值相比,在45天之内提供了化合物出乎意料的高稳定性。效果:提供了化合物的高稳定性。; 5 cl,7 ex

著录项

  • 公开/公告号RU2341266C2

    专利类型

  • 公开/公告日2008-12-20

    原文格式PDF

  • 申请/专利权人 NOVARTIS AG;

    申请/专利号RU20040129281

  • 申请日2003-02-27

  • 分类号A61K31/501;A61K31/496;A61L29/16;A61L31/16;A61F2/06;A61P9/10;

  • 国家 RU

  • 入库时间 2022-08-21 19:10:44

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