DNA-VACCINE AGAINST TUMORAL GROWTH AND WAYS OF THEIR APPLICATION

摘要

FIELD: medicine; biotechnologies.;SUBSTANCE: DNA-vaccine is intended for activation of the immune response against the cancer cells, containing the design of DNA operably coding survivin protein and cytokine CCL21, built in attenuated vector Salmonella typhimurium. The way of inhibition of growth of a tumour by vaccine introduction under the invention to a mammal is opened. The product containing the described vaccine is presented. The way of vaccination of a mammal against a cancer where the way includes a stage of introduction to a mammal of effective quantity of the described DNA-vaccine causing the immune response is offered.;EFFECT: expansion of assortment of DNA-vaccines causing the immune response and unexpectedly high level of cytotoxicity against tumoral cells.;21 cl, 42 dwg, 6 tbl, 22 ex