Process for producing N- 5- (diphenylphosphinoylmethyl) -4- (4-fluorophenyl) -6-isopropylpyrimidin-2-yl -N-methylmethanesulfonamide

摘要

N-(5-(diphenylphosphinoylmethyl)-4-(4-fluorophenyl)-6- isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide (I) is prepared by reaction of (4-(4- fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonyl-aminopyrimidin- 2-yl)methanol (II) with chlorodiphenylphosphine (III). Preparation of N-(5-(diphenylphosphinoylmethyl)-4-(4-fluorophenyl)-6- isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide of formula (I) comprises the reaction of (4-(4- fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonyl-aminopyrimidin- 2-yl)methanol of formula (II) with (III). Ph = phenyl; and Ph' = 4-fluorophenyl.