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Immunizing compositions encoding an epitope obtained from the HIV-1 capsid protein cyclophilin A binding site
Immunizing compositions encoding an epitope obtained from the HIV-1 capsid protein cyclophilin A binding site
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机译:编码从HIV-1衣壳蛋白亲环蛋白A结合位点获得的表位的免疫组合物
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摘要
The present invention relates to an immunogenic composition. More particularly, the present invention is a composition directed to eliciting an immune response to at least one binding site of Cyclophilin A on the HIV capsid protein. (SEQ ID NOS: 2, 4, and 6) The present invention contemplates three categories of embodiments: protein or protein fragments (SEQ ID NOS: 2, 4, and 6), messenger RNA, or DNA/RNA. DNA/RNA compositions (SEQ ID NOS 1, 3, 5, 7, 9, and 11) may be either naked or recombinant. The present invention further contemplates use with a variety of immune stimulants.
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机译:本发明涉及免疫原性组合物。更具体地,本发明是针对引起针对HIV衣壳蛋白上的亲环蛋白A的至少一个结合位点的免疫应答的组合物。 (SEQ ID NOS:2、4和6)本发明考虑了三类实施方案:蛋白质或蛋白质片段(SEQ ID NOS:2、4和6),信使RNA或DNA / RNA。 DNA / RNA组合物(SEQ ID NOS 1、3、5、7、9和11)可以是裸露的或重组的。本发明进一步考虑与多种免疫刺激剂一起使用。
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