Substituted 1-propinylpiperazines with affinity for the MGluR5 receptor for the treatment of pain states

摘要

Substituted 1-propiolylpiperazine compounds corresponding to formula I in which X denotes N or C-RSUP2/SUP, and n is an integer from 0 to 8, a method for producing such substituted 1-propiolylpiperazine compounds, pharmaceutical compositions containing such substituted 1-propiolylpiperazine compounds, and the use of such substituted 1-propiolylpiperazine compounds for modulating mGluR5 receptor activity or for treating or inhibiting pain and various other conditions, especially conditions at least partly mediated by the mGluR5 receptor.