首页> 外国专利> TRANSDERMALLY ABSORBABLE PREPARATION CONTAINING BASIC ANTI-INFLAMMATORY ANALGESIC

TRANSDERMALLY ABSORBABLE PREPARATION CONTAINING BASIC ANTI-INFLAMMATORY ANALGESIC

机译:含基本抗炎镇痛药的透皮吸收制剂

摘要

Disclosed is a transdermal preparation in which a basic anti-inflammatory agent is blended. The transdermal preparation is an adhesive patch for external use, which has excellent drug release properties without deteriorating the physical properties of the plaster. The transdermal preparation is capable of achieving high release properties for the basic anti-inflammatory agent without deteriorating the release properties for a local anesthetic. Specifically disclosed is an adhesive transdermal patch which is characterized by containing both a basic anti-inflammatory agent and a local anesthetic that serves as an absorption enhancer for the basic anti-inflammatory agent. The basic anti-inflammatory agent has an acid dissociation constant (pKa) of not less than 7. The basic anti-inflammatory agent is contained therein in an amount of 0.1-10% by weight relative to the total weight of the drug-containing plaster, and the absorption enhancer is contained therein in an amount of 0.01-20% by weight relative to the total weight of the drug-containing plaster.
机译:公开了其中掺入了基本抗炎剂的透皮制剂。所述透皮制剂是供外部使用的胶粘剂贴剂,其具有优异的药物释放性能,而不会降低膏药的物理性能。所述透皮制剂能够实现对基本抗炎剂的高释放特性,而不会恶化局部麻醉剂的释放特性。具体公开了一种粘合的透皮贴剂,其特征在于同时包含碱性抗炎剂和用作基本抗炎剂的吸收促进剂的局部麻醉剂。碱性抗炎剂的酸解离常数(pKa)不小于7。相对于含药膏药的总重量,碱性抗炎剂的含量为0.1-10重量%。相对于含药膏药的总重量,吸收促进剂的含量为0.01-20重量%。

著录项

  • 公开/公告号CA2783569A1

    专利类型

  • 公开/公告日2011-06-23

    原文格式PDF

  • 申请/专利权人 TEIKOKU SEIYAKU CO. LTD.;

    申请/专利号CA20102783569

  • 发明设计人 KATAYAMA AKIKO;INOO KATSUYUKI;

    申请日2010-12-14

  • 分类号A61K9/70;A61K31/167;A61K31/245;A61K31/42;A61P23/02;A61P29;

  • 国家 CA

  • 入库时间 2022-08-21 18:01:47

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