ORAL LIQUID FORMULATION COMPRISING SALBUTAMOL AND GUAIFENESIN

摘要

The present invention provides an improved pharmaceutical composition which comprises an aqueous dispersion of one or more cellulose derivatives containing salbutamol and/or one or more of its physiologically acceptable salts and guaiphenesin. The pH of the formulation has been maintained at around 4.5 with citrate buffer for better stability of salbutamol. The liquid formulation of the present invention is found to be stable over its shelf life as confirmed by accelerated studies. The present invention is also directed to an innovative process of formulating an oral liquid dosage form containing Salbutamol sulphate and Guaiphenesin as APIs, and possessing good stability coupled with palatability. The invention is useful as a treatment of Asthma, and used as bronchodilator and expectorant in certain respiratory conditions.