N-PIPERAZINYL HETARYLARYLSUFONAMIDE COMPOUNDS WITH AFFINITY FOR THE DOPAMINE D3 RECEPTOR

摘要

The invention related to N-[(piperazinyl)hetaryl]arylsulfonamide compounds of the general formula (I) in which Q is a bivalent, 6-membered heteroaromatic radical which possesses 1 or 2 N atoms as ring members and which optionally carries one or two substituents R^a which is/are selected, independently of each other, from halogen, CN, NO₂, CO₂R⁴, COR⁵, C₁-C₄-alkyl and C₁-C₄-haloalkyl; Ar is phenyl or a 6-membered heteroaromatic radical which possesses 1 or 2 N atoms as ring members and which optionally carries one or two substituents R^b, which is/are selected from halogen, NO₂, CN, CO₂R⁴, COR⁵, C₁-C₆-alkyl, C₂-C₆-alkenyl, C₂-C₆-alkynyl, C₃-C₆-cycloalkyl, C₃-C₆-cycloalkyl-C₁-C₄-alkyl and C₁-C₄-haloalkyl, with it also being possible for two radicals R^b which are bonded to adjacent C atoms of Ar to be together C₃-C₄-alkylene; R¹ is hydrogen, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₃-C₆-cycloalkyl, C₃-C₆-cycloalkyl-C₁-C₄-alkyl, C₁-C₄-hydroxyalkyl, C₁-C₄-alkoxy-C₁-C₄-alkyl, C₃-C₄-alkenyl or C₃-C₄-alkynyl; with the radicals n, R¹, R², R³, R⁴ and R⁵ having the meanings given in the patent claims, to the N-oxides and to the physiologically tolerated acid addition salts of these compounds and to pharmaceutical compositions which comprise at least one N-[(piperazinyl)hetaryl]arylsulfonamide compound as claimed in one of claims 1 to 10 and/or at least one physiologically tolerated acid addition salt of I and/or an N-oxide of I, where appropriate together with physiologically acceptable carriers and/or auxiliary substances for treating diseases which respond to influencing by dopamine D₃ receptor antagonists or agonists, in particular for treating diseases of the central nervous system and disturbances of kidney function.;