N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO 2,3-dPYRIMIDINES AND PYRROL-3-YL-PYRROLO 2,3-dPYRRIMIDINES AS JANUS KINASE INHIBITORS

摘要

The present invention relates to N-(hetero)aryl-pyrrolidine derivatives of Formula I: which are JAK inhibitors, such as selective JAK1 inhibitors, useful in the treatment of JAK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.