Identification of 5-(2,3-Dihydro-1H-indo1-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Derivatives as a New Class of Receptor-Interacting Protein Kinase 1 (RIPK1) Inhibitors, Which Showed Potent Activity in a Tumor Metastasis Model (vol 61, pg 11398, 2018)

Li Yueshan; Xiong Yu; Zhang Guo; Zhang Liting; Yang Wei; Yang Jiao; Huang Luyi; Qiao Zeen; Miao Zhuang; Lin Guifeng; Sun Qiu; Niu Ting; Chen Lijuan; Niu Dawen; Li Linli; Yang Shengyong

首页> 外文期刊>Journal of Medicinal Chemistry >Identification of 5-(2,3-Dihydro-1H-indo1-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Derivatives as a New Class of Receptor-Interacting Protein Kinase 1 (RIPK1) Inhibitors, Which Showed Potent Activity in a Tumor Metastasis Model (vol 61, pg 11398, 2018)

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Identification of 5-(2,3-Dihydro-1H-indo1-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Derivatives as a New Class of Receptor-Interacting Protein Kinase 1 (RIPK1) Inhibitors, Which Showed Potent Activity in a Tumor Metastasis Model (vol 61, pg 11398, 2018)

机译：鉴定5-（2,3-二氢-1H- Indo1-5-1-1-5-1-1-5-基嘧啶[2,3-D]嘧啶-4-胺衍生物作为新类受体相互作用蛋白激酶1（RIPK1）抑制剂，其显示在肿瘤转移模型中有效的活性（Vol 61，PG 11398,2018）

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来源
《Journal of Medicinal Chemistry》 |2019年第6期|共1页
作者
Li Yueshan; Xiong Yu; Zhang Guo; Zhang Liting; Yang Wei; Yang Jiao; Huang Luyi; Qiao Zeen; Miao Zhuang; Lin Guifeng; Sun Qiu; Niu Ting; Chen Lijuan; Niu Dawen; Li Linli; Yang Shengyong;
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1. Identification of 5-(2,3-Dihydro-1H-indo1-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Derivatives as a New Class of Receptor-Interacting Protein Kinase 1 (RIPK1) Inhibitors, Which Showed Potent Activity in a Tumor Metastasis Model (vol 61, pg 11398, 2018) [J] . Li Yueshan, Xiong Yu, Zhang Guo, Journal of Medicinal Chemistry . 2019,第6期

机译：鉴定5-（2,3-二氢-1H- Indo1-5-1-1-5-1-1-5-基嘧啶[2,3-D]嘧啶-4-胺衍生物作为新类受体相互作用蛋白激酶1（RIPK1）抑制剂，其显示在肿瘤转移模型中有效的活性（Vol 61，PG 11398,2018）
2. Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro- 1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) [J] . Axten J.M., Medina J.R., Feng Y., Journal of Medicinal Chemistry . 2012,第16期

机译：7-甲基-5-（1-{[3-（三氟甲基）苯基]乙酰基} -2,3-二氢-1H-吲哚-5-基）-7H-吡咯并[2,3-d]嘧啶-的发现4-胺（GSK2606414），一种有效的选择性蛋白激酶R（PKR）样内质网激酶（PERK）的一流抑制剂
3. Design, synthesis and evaluation of novel 7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives as potent, selective and reversible Bruton's tyrosine kinase (BTK) inhibitors for the treatment of rheumatoid arthritis [J] . Zhang Chufeng, Pei Heying, He Jun, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2019,第期

机译：新颖的7H-吡咯的嘧啶-4-胺衍生物的设计，合成和评价为有效，选择性和可逆的Bruton的酪氨酸激酶（BTK）抑制剂，用于治疗类风湿性关节炎
4. Discovery of potent necroptosis inhibitors targeting RIPK1 kinase activity for the treatment of inflammatory disorder and cancer metastasis [O] . Jue Hou, Jie Ju, Zili Zhang, 2019

机译：发现靶向RIPK1激酶活性的强效坏死性抑制剂可治疗炎性疾病和癌症转移
5. Correction to Identification of 5-(2,3-Dihydro-1H-indol-5-yl)-7H-pyrrolo2,3-dpyrimidin-4-amine Derivatives as a New Class of Receptor-Interacting Protein Kinase 1 (RIPK1) Inhibitors, Which Showed Potent Activity in a Tumor Metastasis Model [O] . Yueshan Li, Yu Xiong, Guo Zhang, 2019

机译：校正5-（2,3-二氢-1H-吲哚-5-基）-7H-吡咯的嘧啶-4-胺衍生物作为一种新的受体相互作用蛋白激酶1（ RIPK1）抑制剂，其显示在肿瘤转移模型中的有效活性

Identification of 5-(2,3-Dihydro-1H-indo1-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Derivatives as a New Class of Receptor-Interacting Protein Kinase 1 (RIPK1) Inhibitors, Which Showed Potent Activity in a Tumor Metastasis Model (vol 61, pg 11398, 2018)

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